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The above-linked article on the investigation of the molecular motor of muscle mentions groundbreaking work that his lab did in isolation during World War II. I was fortunate to hear him give a lecture aimed at the generalist.Īlbert is worthy of note because receiving the 1937 Nobel in Physiology or Medicine did not lead him to cease conducting pioneering research. His English was first-rate, an accomplishment since English and Hungarian are not related, and learning either is difficult for the person whose language is the other. Despite their challenging nature and having very few related sequences, we achieved a high degree of accuracy on both of our predictions when compared to their experimentally determined structures. Impressively quick work by experimentalists has now confirmed the structures of both ORF3a and ORF8. At CASP14, we predicted the structure of another coronavirus protein, ORF8. Earlier this year, we predicted several protein structures of the SARS-CoV-2 virus, including ORF3a, whose structures were previously unknown. We’ve also seen signs that protein structure prediction could be useful in future pandemic response efforts, as one of many tools developed by the scientific community.
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These insights could enable more precise work on drug development, complementing existing experimental methods to find promising treatments faster.
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In the meantime, we’re also looking into how protein structure predictions could contribute to our understanding of specific diseases with a small number of specialist groups, for example by helping to identify proteins that have malfunctioned and to reason about how they interact. This is really interesting work in life science and work in drug discovery, driven by computation: Below is a note that I sent to my colleagues at the end of 2020, when last winter's COVID outbreaks were at a terrible high. My day job is technical support for basic research in life science, and abuts drug discovery, which is targeted work.